Analytical Data
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Gene name
Sorcin/SRI
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简介
The Sorcin/SRI protein is a calcium-binding regulator that complexly regulates excitation-contraction coupling in the heart and plays a critical role in maintaining calcium homeostasis within the sarcoplasmic reticulum. As a homodimer, Sorcin/SRI affects the activity of the RYR2 calcium channel, helping to precisely control calcium dynamics in cardiomyocytes. Sorcin/SRI Protein, Human (sf9) is the recombinant human-derived Sorcin/SRI protein, expressed by Sf9 insect cells , with tag free.
- Application
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Alternative Names
22 kDa protein; CP22; V19
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Species
Human
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Source
Baculovirus
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P30626
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Expression Region
M1-V198
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Protein Length
Full Length
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Molecular Weight
20 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Sorcin, also known as SRI (Stress-Response Protein), is a calcium-binding protein belonging to the S100 family that plays a critical role in various cellular processes, including calcium homeostasis, cell proliferation, and apoptosis. Research into Sorcin has gained momentum due to its involvement in the regulation of heart function and its potential link to various pathologies, such as cancer and cardiac diseases. In particular, Sorcin has been implicated in the development of drug resistance in cancer cells, making it a target of interest in the field of cancer therapeutics. The recombinant expression of Sorcin facilitates detailed studies of its structure and function, allowing for the characterization of its interaction with calcium ions and other cellular components. The ability to produce recombinant Sorcin in a controlled environment provides an opportunity to explore its biochemical properties and functional mechanisms further, with potential applications in drug development and disease therapeutics. Overall, the investigation of Sorcin/SRI recombinant protein is crucial for understanding its role in health and disease, which may lead to novel therapeutic strategies targeting its signaling pathways.
