Analytical Data
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Gene name
COL4A3BP
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简介
COL4A3BP, a lipid-binding molecule, crucially facilitates intracellular trafficking of ceramides and diacylglycerol lipids via its START domain using a non-vesicular mechanism. COL4A3BP Protein, Human (sf9, His-GST) is the recombinant human-derived COL4A3BP protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- Application
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Alternative Names
Ceramide transfer protein; hCERT; GPBP; StARD11; CERT1
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Species
Human
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Source
Baculovirus
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Tag
N-His;N-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y5P4
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Expression Region
M1-F598
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Protein Length
Partial
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Molecular Weight
96 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COL4A3BP, or Collagen Type IV Alpha 3 Binding Protein, plays a crucial role in the cellular interactions and structural integrity of tissues. Its primary function is to bind collagen, a vital component of the extracellular matrix, which is essential for maintaining the structural framework of various tissues. Research has implicated COL4A3BP in several pathological conditions, including kidney diseases and tumors, highlighting its potential as a biomarker and therapeutic target. The interest in recombinant COL4A3BP proteins stems from their applications in studying the molecular mechanisms underlying these diseases, as well as their utility in developing new diagnostic tools. Recombinant proteins enable researchers to investigate the protein's interactions, functional domains, and effects on cellular behavior in vitro and in vivo. Moreover, understanding COL4A3BP could lead to innovative treatment strategies that manipulate its interactions to restore normal tissue function or inhibit tumor progression. Thus, the study of COL4A3BP encompasses fundamental biological research and the potential for clinical applications, making it a significant focus in biomedical research.
