Analytical Data
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Gene name
RAB31
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简介
RAB31 protein binds GDP and GTP and participates in processes like protein transport, insulin response, and receptor internalization. It is mainly located in the early endosome, phagocytic vesicle, and trans-Golgi network membrane. RAB31 is also a biomarker for severe acute respiratory syndrome and is broadly expressed in tissues such as the brain, adrenal glands, and 22 others. RAB31 Protein, Human (His) is the recombinant human-derived RAB31 protein, expressed by E. coli , with N-His labeled tag.
- Application
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Alternative Names
Ras-related protein Rab-31; Ras-related protein Rab-22B; RAB31; RAB22B
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13636
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Expression Region
M1-C195
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Protein Length
Full Length
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Molecular Weight
26 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RAB31 is a member of the RAB GTPase family, which plays a crucial role in intracellular vesicle transport, particularly in the regulation of exocytosis and endocytosis processes. Abnormalities in RAB31 function have been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. Research into RAB31 has gained momentum as scientists are keen to understand its molecular mechanisms and interactions within the cellular environment. The recombinant expression of RAB31 allows for the study of its biochemical properties, functional assays, and potential therapeutic applications. By generating RAB31 as a recombinant protein, researchers can explore its role in membrane trafficking, cell signaling, and its interactions with other cellular proteins. This protein can also serve as a biomarker for disease states or as a target for drug development, making it a focal point in studies aimed at unraveling the complexities of cell biology and disease mechanisms. Understanding RAB31 not only enhances our comprehension of fundamental cellular processes but may also pave the way for innovative therapeutic strategies in the treatment of diseases associated with RAB dysfunction.
