Analytical Data
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Gene name
BPIFB1
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简介
The BPIFB1 protein may play a crucial role in innate immunity, particularly in the mouth, nose, and lungs, against microbial threats. It binds to bacterial lipopolysaccharide (LPS), modulates cellular responses and affects LPS-triggered immune signaling pathways. BPIFB1 Protein, Human (HEK293, His) is the recombinant human-derived BPIFB1 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
BPI fold-containing family B member 1; VEMSGP; BPIFB1; C20orf114; LPLUNC1
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Species
Human
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8TDL5
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Expression Region
T22-Q484
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Protein Length
Full Length of Mature Protein
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Molecular Weight
53 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BPIFB1 (Bactericidal Permeability-Increasing Protein Family, member B1) is a member of the BPI/PLUNC protein family, which plays a crucial role in the immune response and host defense mechanisms. Research into BPIFB1 has gained significance due to its potential implications in respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), as well as its involvement in innate immune response to bacterial infections. Studies have shown that BPIFB1 can modulate inflammatory processes and influence the activity of immune cells, suggesting it serves a protective role in maintaining lung health. Additionally, BPIFB1 has been linked to the regulation of surfactant homeostasis and airway epithelial integrity, both of which are vital for normal respiratory function. Given its multifaceted role, recombinant BPIFB1 protein has become an attractive target for therapeutic development and biomarker discovery, prompting researchers to explore its structure, function, and potential applications in clinical settings. Enhanced understanding of BPIFB1 could significantly advance the development of novel treatment strategies aimed at diseases affecting the respiratory system.
