Analytical Data
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Gene name
PCDH7
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简介
PCDH7 Protein, an integral membrane protein, belongs to the PCDHδ1 subfamily and it is highly expressed in brain and heart. PCDH7 is a synaptically localized, GluN1-interacting protein that regulates synapse morphology and function. PCDH7 is the first trans-membrane protein that inhibits homotypic cell-in-cell (hoCIC) formation to promote tumor growth[1][2]. PCDH7 Protein, Human (sf9, His) is the recombinant human-derived PCDH7 protein, expressed by Sf9 insect cells , with N-His labeled tag.
- Application
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Alternative Names
Protocadherin-7; Brain-heart protocadherin; BH-Pcdh; PCDH7; BHPCDH
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Species
Human
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Source
Baculovirus
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O60245-1
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Expression Region
A29-S879
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Protein Length
Extracellular Domain
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Molecular Weight
94 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PCDH7, or protocadherin 7, is a member of the cadherin superfamily, which plays a critical role in cell adhesion, signaling, and neuronal development. Research has indicated that PCDH7 is involved in various biological processes, including cell migration, differentiation, and apoptosis, suggesting its significance in both normal physiology and disease states. Its abnormal expression has been linked to several cancers and neurodegenerative disorders, which makes it a potential biomarker for diagnostic and therapeutic applications. The production of recombinant PCDH7 protein has gained attention as it allows for in-depth structural and functional studies. Understanding the functional properties and interaction networks of PCDH7 can provide insights into its role in cell communication and the pathological mechanisms underlying related diseases. Moreover, recombinant PCDH7 can serve as a tool for developing new therapeutic strategies aimed at modulating its activity. The ability to produce this protein in a controlled environment facilitates high-resolution studies using techniques like crystallography and NMR spectroscopy, helping to elucidate the molecular mechanisms by which PCDH7 contributes to cellular processes. Overall, research on recombinant PCDH7 protein is pivotal not only for advancing our understanding of cadherin-mediated cell signaling but also for exploring its potential applications in biomedical research and clinical therapies.
