Analytical Data
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Gene name
NRXN3/Neurexin-3
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简介
Neurexin-3-beta is neuronal cell surface protein that is involved in cell recognition and cell adhesion. Neurexin-3-beta mediates intracellular signaling. NRXN3/Neurexin-3 Protein, Human (HEK293, Fc) is the recombinant human-derived NRXN3/Neurexin-3 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
Neurexin-3-beta; Neurexin III-beta; NRXN3-CTF; NRXN3; KIAA0743
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9HDB5-2
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Expression Region
S36-T357
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Protein Length
Partial
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Molecular Weight
75-85 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Neurexin-3 (NRXN3) is a member of the neurexin family of proteins, which are crucial for synapse formation and function in the nervous system. These proteins, primarily expressed in the brain, play a significant role in mediating neuron-glia interactions and synaptic transmission by binding to neuroligins and other partners. Recent studies have linked genetic variants in NRXN3 to neurodevelopmental disorders, including autism spectrum disorders (ASD) and schizophrenia, highlighting its importance in neurobiology. Understanding the structure and function of NRXN3 is essential for elucidating its role in synaptic physiology and its involvement in these disorders. Researchers have turned to the production of recombinant NRXN3 proteins to study their biochemical properties, interactions with ligands, and impact on synaptic plasticity. The ability to generate pure and functional NRXN3 in vitro provides a valuable tool for investigating its mechanisms of action, potential therapeutic targets, and the development of strategies to mitigate the effects of NRXN3-associated disorders. Given the growing emphasis on personalized medicine and targeted therapies for neurodevelopmental conditions, understanding NRXN3's role could pave the way for novel interventions.
