Analytical Data
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Gene name
RP2
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简介
The RP2 protein is a GTPase-activating protein (GAP) that regulates intracellular trafficking between the Golgi apparatus and the ciliary membrane. It ensures the precise localization of proteins such as NPHP3 to the ciliary membrane by catalyzing the hydrolysis of GTP ARL3, resulting in the release of UNC119 (or UNC119B). RP2 Protein, Human (sf9, GST) is the recombinant human-derived RP2 protein, expressed by Sf9 insect cells , with N-GST labeled tag.
- Application
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Alternative Names
Protein XRP2; RP2
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Species
Human
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Source
Baculovirus
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Tag
N-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75695
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Expression Region
M1-T350
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Protein Length
Full Length
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Molecular Weight
66 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RP2 is a protein encoded by the RP2 gene, which is located on the X chromosome and is primarily associated with X-linked retinitis pigmentosa, a genetic disorder leading to progressive retinal degeneration. Research into RP2 is crucial not only for understanding the molecular mechanisms underlying retinitis pigmentosa but also for exploring potential therapeutic interventions. RP2 plays a significant role in the trafficking and function of signaling proteins in photoreceptor cells, and its dysfunction can lead to the accumulation of toxic products and cell death. The importance of RP2 extends beyond retinitis pigmentosa, as mutations in the RP2 gene have also been implicated in other conditions such as syndromic retinal disease and intelleсtual disability. Advances in recombinant protein technologies allow for the production of RP2 proteins in various systems, enabling detailed studies of their structure, function, and interactions with other cellular components. This research is vital for developing gene therapies and other treatment modalities aimed at mitigating the effects of RP2 mutations, ultimately leading to improved outcomes for affected individuals. As our understanding of RP2 continues to deepen, it may pave the way for innovative approaches in the field of gene therapy and protein replacement therapies for those suffering from inherited retinal diseases.
