Analytical Data
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Gene name
HNRNPR
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简介
hnRNP-R Protein, a constituent of ribonucleosomes, participates in precursor mRNA processing within the nucleus. It's part of the spliceosome C complex and involved in IGF2BP1-dependent mRNP granule complexes containing untranslated mRNAs. Additionally, hnRNP-R interacts with GTPBP1. HNRNPR Protein, Human (sf9, His-GST) is the recombinant human-derived hnRNP-R protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- Application
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Alternative Names
Heterogeneous nuclear ribonucleoprotein R; hnRNP R; HNRNPR
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Species
Human
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Source
Baculovirus
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Tag
N-His;N-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43390-2
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Expression Region
A2-K636
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Protein Length
Full Length of Isoform-2
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Molecular Weight
114 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HNRNPR (heterogeneous nuclear ribonucleoprotein R) is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, which plays a crucial role in pre-mRNA processing and gene regulation. Research has indicated that HNRNPR is involved in various cellular processes, including splicing, RNA transport, and stabilization, contributing to the regulation of gene expression. Dysregulation of HNRNPR has been implicated in several diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. Studies focus on the structural and functional characterization of HNRNPR, especially in understanding its interactions with RNA and other proteins, which are essential for its role in mRNA metabolism. Recombinant HNRNPR protein production enables researchers to investigate its biochemical properties and functional dynamics in various cellular contexts. This research not only enhances our understanding of the molecular mechanisms governing gene regulation but also explores the potential of HNRNPR as a biomarker or target for innovative treatments in diseases marked by altered RNA processing. Thus, the study of HNRNPR and its recombinant forms is vital for elucidating its contributions to cellular homeostasis and pathology.
