Analytical Data
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基因名
HNRNPR
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简介
hnRNP-R Protein, a constituent of ribonucleosomes, participates in precursor mRNA processing within the nucleus. It's part of the spliceosome C complex and involved in IGF2BP1-dependent mRNP granule complexes containing untranslated mRNAs. Additionally, hnRNP-R interacts with GTPBP1. HNRNPR Protein, Human (sf9, His-GST) is the recombinant human-derived hnRNP-R protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- Application
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别名
Heterogeneous nuclear ribonucleoprotein R; hnRNP R; HNRNPR
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种属
Human
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表达系统
Baculovirus
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标签
N-His;N-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43390-2
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表达区间
A2-K636
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蛋白长度
Full Length of Isoform-2
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分子量
114 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HNRNPR (heterogeneous nuclear ribonucleoprotein R) is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, which plays a crucial role in pre-mRNA processing and gene regulation. Research has indicated that HNRNPR is involved in various cellular processes, including splicing, RNA transport, and stabilization, contributing to the regulation of gene expression. Dysregulation of HNRNPR has been implicated in several diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. Studies focus on the structural and functional characterization of HNRNPR, especially in understanding its interactions with RNA and other proteins, which are essential for its role in mRNA metabolism. Recombinant HNRNPR protein production enables researchers to investigate its biochemical properties and functional dynamics in various cellular contexts. This research not only enhances our understanding of the molecular mechanisms governing gene regulation but also explores the potential of HNRNPR as a biomarker or target for innovative treatments in diseases marked by altered RNA processing. Thus, the study of HNRNPR and its recombinant forms is vital for elucidating its contributions to cellular homeostasis and pathology.
