Analytical Data
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基因名
p63/TP73L
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简介
The p63/TP73L protein is a sequence-specific DNA-binding transcriptional regulator that exhibits diverse activities through its isoforms. Isoform 2 activates RIPK4 transcription, and binding of this protein to TP73/p73 initiates p53/TP53-dependent apoptosis in response to genotoxic stress. p63/TP73L Protein, Human (sf9, His-GST) is the recombinant human-derived p63/TP73L protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- Application
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别名
Tumor protein 63; p63; CUSP; TP63; p73L
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种属
Human
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表达系统
Baculovirus
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标签
N-His;N-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H3D4
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表达区间
M1-E680
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蛋白长度
Full Length
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分子量
125 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
p63 and TP73L are members of the p53 protein family, which play significant roles in cellular processes such as development, differentiation, and responses to stress. p63 is known for its critical role in the development of ectodermal tissues and is involved in the regulation of epidermal stem cells. TP73L, a variant of the TP73 gene, shares structural and functional similarities with p53 but is primarily involved in neurogenesis and apoptosis. The study of recombinant proteins like p63 and TP73L is crucial for understanding their specific functions and interactions within cellular pathways. Research has revealed that dysregulation of p63 and TP73L can contribute to various diseases, including cancer. Therefore, generating recombinant versions of these proteins allows for in-depth biochemical analysis, structural studies, and exploration of their potential as therapeutic targets. This knowledge is essential for developing novel strategies in regenerative medicine and cancer therapy. The investigation of p63 and TP73L also provides insights into the evolutionary aspects of the p53 family, contributing to a broader understanding of cellular responses across different species. Overall, the research on p63 and TP73L recombinant proteins is pivotal in elucidating their roles in health and disease.
