Analytical Data
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Gene name
H2BC11
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简介
The H2BC11 protein functions as a core component of nucleosomes, the fundamental units in chromatin structure that wrap and compact DNA, regulating its accessibility to cellular processes that require DNA as a template. Histones, including H2BC11, play central roles in transcriptional regulation, DNA repair, DNA replication, and chromosome stability. H2BC11 Protein, Human is the recombinant human-derived H2BC11 protein, expressed by E. coli , with tag free.
- Application
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Alternative Names
H2BC11; Histone H2B type 1-J
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P06899
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Expression Region
P2-K126
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Protein Length
Full Length of Mature Protein
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Molecular Weight
13.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
H2BC11 is a histone H2B variant that has garnered increased attention in the field of epigenetics and chromatin biology due to its potential roles in gene regulation and chromatin dynamics. Histone variants are known to influence the structure and function of chromatin, thereby affecting transcriptional activity and cellular processes such as differentiation and development. H2BC11, specifically, has been implicated in modulating the epigenetic landscape through mechanisms that may involve post-translational modifications and interactions with other chromatin-associated proteins. Research on H2BC11 aims to elucidate its specific functional roles in various biological contexts, including its contribution to maintaining genomic stability and its potential implications in diseases such as cancer. The recombinant production of H2BC11 facilitates detailed biochemical studies that can uncover its mechanisms of action, binding partners, and the impact of its modifications on chromatin structure and function. Understanding the intricate roles of H2BC11 can provide valuable insights into broader epigenetic regulation and may pave the way for novel therapeutic strategies targeting chromatin-related disorders. Thus, H2BC11 serves as an intriguing subject of investigation within the broader narrative of histone research and its implications for gene expression and cellular identity.
