Analytical Data
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Gene name
H2AC4
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简介
The H2AC4 protein is a core component of nucleosomes, which compress DNA into chromatin and restrict DNA entry into cellular processes. H2AC4 Protein, Human is the recombinant human-derived H2AC4 protein, expressed by E. coli , with tag free.
- Application
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Alternative Names
" Histone H2A type 1-B/E; Histone H2A.2; Histone H2A/a; Histone H2A/m; H2AFM"
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P04908
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Expression Region
S2-K130
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Protein Length
Full Length of Mature Protein
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Molecular Weight
14.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
H2AC4 is a member of the histone H2A family, known for its role in packaging and organizing DNA within the nucleus of eukaryotic cells. Histones are essential for the formation of nucleosomes, which are the fundamental units of chromatin, thus playing a crucial role in gene regulation, DNA replication, and repair. Research on H2AC4 has gained momentum due to its potential implications in understanding epigenetic modifications and their impact on cellular processes. Alterations in histone variants, including H2AC4, are linked to various diseases, including cancer, where changes in gene expression patterns can lead to uncontrolled cell proliferation. Advances in proteomics and molecular biology techniques have facilitated detailed studies of the structure and function of H2AC4, revealing its unique properties and interactions with other nuclear proteins. Understanding the mechanisms governing H2AC4's function and regulation may provide insights into the broader epigenetic landscape and identify novel therapeutic targets for diseases associated with dysregulated histone modification. Moreover, H2AC4 could serve as a valuable biomarker for certain pathological conditions, highlighting the importance of continued research in this field. Overall, the study of H2AC4 not only enhances our understanding of fundamental biological processes but also contributes to the development of innovative diagnostic and therapeutic strategies.
