Analytical Data
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基因名
PTPRC/CD45RA
- Application
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别名
Leukocyte common antigen
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P08575
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表达区间
26-577aa
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分子量
76.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTPRC, commonly known as CD45, is a critical receptor-type protein tyrosine phosphatase primarily expressed on the surface of immune cells, including T and B lymphocytes. It plays a pivotal role in regulating immune cell activation, differentiation, and signaling pathways. The isoform CD45RA is particularly significant, as it is associated with naive T cells and has been implicated in various immune responses and diseases. Research into the recombinant production of PTPRC/CD45RA protein allows scientists to obtain large quantities of this important molecule for various applications, including structural studies, functional assays, and therapeutic development. Understanding the functional implications of CD45RA on lymphocyte signaling can provide insights into the mechanisms underlying immune responses and the pathogenesis of disorders like autoimmunity and cancer. Moreover, recombinant CD45RA has potential as a biomarker for assessing T cell status and as a target for immunotherapy approaches. By producing and characterizing this protein, researchers aim to better understand its role in immune modulation and develop novel strategies to manipulate immune responses in clinical settings.
