Analytical Data
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Gene name
PTPRC/CD45RA
- Application
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Alternative Names
Leukocyte common antigen
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P08575
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Expression Region
26-577aa
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Molecular Weight
76.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PTPRC, commonly known as CD45, is a critical receptor-type protein tyrosine phosphatase primarily expressed on the surface of immune cells, including T and B lymphocytes. It plays a pivotal role in regulating immune cell activation, differentiation, and signaling pathways. The isoform CD45RA is particularly significant, as it is associated with naive T cells and has been implicated in various immune responses and diseases. Research into the recombinant production of PTPRC/CD45RA protein allows scientists to obtain large quantities of this important molecule for various applications, including structural studies, functional assays, and therapeutic development. Understanding the functional implications of CD45RA on lymphocyte signaling can provide insights into the mechanisms underlying immune responses and the pathogenesis of disorders like autoimmunity and cancer. Moreover, recombinant CD45RA has potential as a biomarker for assessing T cell status and as a target for immunotherapy approaches. By producing and characterizing this protein, researchers aim to better understand its role in immune modulation and develop novel strategies to manipulate immune responses in clinical settings.
