Analytical Data
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基因名
PARK7/DJ-1
- Application
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别名
Maillard deglycase (Oncogene DJ1) (Parkinson disease protein 7) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1)
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99497
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表达区间
1-188aa
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分子量
19.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PARK7, also known as DJ-1, is a protein implicated in various neurodegenerative disorders, particularly Parkinson's disease. It serves multiple roles, primarily as a sensor of oxidative stress and a regulator of cellular responses to stress, highlighting its protective function in neuronal cells. Mutations in the PARK7 gene are linked to early-onset familial Parkinson's disease, underscoring its critical role in maintaining neuronal health. The protein is involved in various cellular processes, including mitochondrial function, apoptosis, and transcriptional regulation. Its protective mechanisms are thought to be mediated through its antioxidant properties, as well as its ability to influence signaling pathways that prevent cell death. Moreover, PARK7 is known to interact with several proteins associated with mitochondrial dynamics and inflammation, further establishing its significance in neuroprotection. Given its essential functions, researchers have focused on understanding the structural and functional aspects of DJ-1 to develop potential therapeutic strategies. Studies on PARK7/DJ-1 recombinant proteins aim to elucidate its mechanisms of action, explore its role in oxidative stress response, and identify targets for drug development. Understanding the biochemical pathways involving DJ-1 could lead to innovative treatments for neurodegenerative diseases, providing hope for patients affected by these debilitating conditions.
