Analytical Data
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Gene name
SH3PXD2A
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简介
SH3PXD2A is an adapter protein that plays a crucial role in the formation of invadopodia and podosomes, thereby enhancing the invasiveness of cancer cells. It interacts with ADAM, NOX and phosphoinositides and contributes to a variety of cellular processes. SH3PXD2A Protein, Human (Myc, His) is the recombinant human-derived SH3PXD2A protein, expressed by E. coli , with N-His, C-Myc labeled tag.
- Application
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Alternative Names
Adapter protein TKS5; Five SH3 domain-containing protein; SH3 and PX domain-containing protein 2A; SH3 multiple domains protein 1; Sh3md1; Sh3pxd2a; SPD2A_HUMAN; TKs5; Tyrosine kinase substrate with five SH3 domains
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Species
Human
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Source
E. coli
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Tag
N-His;C-Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5TCZ1
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Expression Region
P902-P986
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SH3PXD2A, a member of the SH3PXD family, has been increasingly recognized for its role in cellular signaling and cytoskeletal dynamics. It encodes a protein that is characterized by the presence of SH3 (Src Homology 3) domains, which are known to mediate protein-protein interactions and play critical roles in various cellular processes, including cell adhesion, migration, and endocytosis. Abnormalities in SH3PXD2A expression have been linked to several pathophysiological conditions, including cancer and developmental disorders, making it a potential biomarker and therapeutic target. Recent studies have focused on the structural and functional characterization of SH3PXD2A, revealing its involvement in key cellular pathways that regulate the actin cytoskeleton. Understanding the molecular mechanisms of SH3PXD2A function could provide insights into its contributions to cell motility and signal transduction. The production of recombinant SH3PXD2A protein is essential for these investigations, as it allows for detailed biochemical and biophysical analyses. This research aims to elucidate the role of SH3PXD2A in health and disease, potentially paving the way for novel therapeutic strategies.
