Analytical Data
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基因名
SH3PXD2A
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简介
SH3PXD2A is an adapter protein that plays a crucial role in the formation of invadopodia and podosomes, thereby enhancing the invasiveness of cancer cells. It interacts with ADAM, NOX and phosphoinositides and contributes to a variety of cellular processes. SH3PXD2A Protein, Human (Myc, His) is the recombinant human-derived SH3PXD2A protein, expressed by E. coli , with N-His, C-Myc labeled tag.
- Application
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别名
Adapter protein TKS5; Five SH3 domain-containing protein; SH3 and PX domain-containing protein 2A; SH3 multiple domains protein 1; Sh3md1; Sh3pxd2a; SPD2A_HUMAN; TKs5; Tyrosine kinase substrate with five SH3 domains
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种属
Human
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表达系统
E. coli
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标签
N-His;C-Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5TCZ1
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表达区间
P902-P986
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SH3PXD2A, a member of the SH3PXD family, has been increasingly recognized for its role in cellular signaling and cytoskeletal dynamics. It encodes a protein that is characterized by the presence of SH3 (Src Homology 3) domains, which are known to mediate protein-protein interactions and play critical roles in various cellular processes, including cell adhesion, migration, and endocytosis. Abnormalities in SH3PXD2A expression have been linked to several pathophysiological conditions, including cancer and developmental disorders, making it a potential biomarker and therapeutic target. Recent studies have focused on the structural and functional characterization of SH3PXD2A, revealing its involvement in key cellular pathways that regulate the actin cytoskeleton. Understanding the molecular mechanisms of SH3PXD2A function could provide insights into its contributions to cell motility and signal transduction. The production of recombinant SH3PXD2A protein is essential for these investigations, as it allows for detailed biochemical and biophysical analyses. This research aims to elucidate the role of SH3PXD2A in health and disease, potentially paving the way for novel therapeutic strategies.
