Analytical Data
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Gene name
LOX-1/OLR1
- Application
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Alternative Names
OLR1; CLEC8A; SCARE1; Oxidized low-density lipoprotein receptor 1; C-type lectin domain family 8 member A; Lectin-like oxidized LDL receptor 1; Lectin-type oxidized LDL receptor 1
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Species
Rabbit
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q9XTA8
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Expression Region
Met55~Glu274
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Molecular Weight
29kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LOX-1 (lectin-like oxidized low-density lipoprotein receptor-1) is a type of scavenger receptor that plays a crucial role in cellular uptake of oxidized low-density lipoproteins (oxLDL), thus contributing to atherogenesis and cardiovascular diseases. It is primarily expressed in endothelial cells, macrophages, and vascular smooth muscle cells, where it is implicated in inflammatory processes and endothelial dysfunction. The binding of oxLDL to LOX-1 triggers several intracellular signaling pathways that promote inflammation, oxidative stress, and apoptosis, which are fundamental in the development of atherosclerosis.
OLR1, the gene encoding LOX-1, has emerged as a significant target for investigating potential therapeutic interventions in vascular diseases. Recombinant LOX-1 protein studies allow for the elucidation of its structure-function relationship, the elucidation of its ligand-binding properties, and the investigation of its signaling mechanisms. Furthermore, understanding LOX-1's interactions with various ligands can provide insights into the pathophysiological roles of this receptor in cardiovascular diseases. As such, research into LOX-1 and its recombinant forms is vital for developing strategies aimed at modulating its activity for therapeutic benefits, particularly in managing conditions associated with dyslipidemia and atherosclerosis. Additionally, recombinant LOX-1 proteins can serve as valuable tools in drug discovery and the development of diagnostic markers, underscoring their importance in cardiovascular research. Overall, the investigation of LOX-1/OLR1 recombinant proteins represents a critical avenue for enhancing our understanding of cardiovascular pathology and potential treatment modalities.
