Analytical Data
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基因名
TXNDC15
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简介
TXNDC15 Protein positively regulates ciliary hedgehog signaling, crucial in cellular communication. It actively participates in ciliogenesis, contributing to the structural and functional dynamics of the cellular organelle. TXNDC15 Protein, Human (HEK293, His) is the recombinant human-derived TXNDC15 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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别名
Thioredoxin domain-containing protein 15; C5orf14; UNQ335/PRO534
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96J42-1
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表达区间
V33-S321
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氨基酸序列
VEVAEESGRLWSEEQPAHPLQVGAVYLGEEELLHDPMGQDRAAEEANAVLGLDTQGDHMVMLSVIPGEAEDKVSSEPSGVTCGAGGAEDSRCNVRESLFSLDGAGAHFPDREEEYYTEPEVAESDAAPTEDSNNTESLKSPKVNCEERNITGLENFTLKILNMSQDLMDFLNPNGSDCTLVLFYTPWCRFSASLAPHFNSLPRAFPALHFLALDASQHSSLSTRFGTVAVPNILLFQGAKPMARFNHTDRTLETLKIFIFNQTGIEAKKNVVVTQADQIGPLPSTLIKS
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蛋白长度
Extracellular Domain
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分子量
50-90 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TXNDC15 is a member of the thioredoxin family, which plays a crucial role in redox regulation and cellular stress responses. The protein is implicated in several cellular processes, including protein folding, degradation, and modulating oxidative stress, indicating its potential significance in various diseases, particularly cancer and neurodegenerative disorders. Recent studies have highlighted its involvement in the endoplasmic reticulum (ER) stress response, suggesting that TXNDC15 may be essential for maintaining cellular homeostasis under stressful conditions. The investigation of TXNDC15 recombinant protein is vital for understanding its structure-function relationship, elucidating its biochemical pathways, and exploring its potential as a therapeutic target. As researchers aim to characterize TXNDC15 further, the availability of recombinant forms of the protein can facilitate functional assays, biochemical interactions, and studies on its role in disease mechanisms. Understanding the precise molecular mechanisms by which TXNDC15 operates may provide new insights into therapeutic strategies for diseases associated with protein misfolding and oxidative stress, ultimately highlighting the importance of redox biology in cellular health.
