Analytical Data
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基因名
TIM-16
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简介
TIM-16 protein is an important component of the PAM complex, which uses ATP to promote the transfer of transit peptide-containing proteins from the inner membrane to the mitochondrial matrix. TIM-16 Protein, S. cerevisiae is the recombinant TIM-16 protein, expressed by E. coli , with tag free.
- Application
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别名
Mitochondrial import inner membrane translocase subunit TIM16; Presequence translocated-associated motor subunit PAM16; PAM16; TIM16
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种属
Others
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P42949
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表达区间
T54-A119
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蛋白长度
Partial
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分子量
11 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TIM-16, a member of the mitochondrial chaperone family, has garnered significant attention in recent years due to its critical role in maintaining mitochondrial function and cellular homeostasis. Mitochondria, often referred to as the powerhouses of the cell, are essential for energy production, and their dysfunction is linked to various diseases, including neurodegenerative disorders and metabolic syndromes. The TIM-16 protein is involved in the translocation of proteins into the mitochondria, facilitating proper mitochondrial biogenesis and dynamics. Research has shown that TIM-16 interacts with other chaperones and proteins in the mitochondrial import machinery, highlighting its importance in protein folding and quality control within this organelle. Understanding the molecular mechanisms governing TIM-16's function could provide insights into the pathophysiology of mitochondrial diseases and reveal potential therapeutic targets. Furthermore, the study of TIM-16 may illuminate broader aspects of cellular stress responses and metabolic regulation, as mitochondria play a central role in these processes. Given the increasing incidence of mitochondrial-related diseases, advancing our understanding of TIM-16 and its biological significance is of paramount importance for developing effective interventions and treatments.
