Analytical Data
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Gene name
CD206/MMR
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简介
The MRC2 protein may function as an endocytic lectin receptor with calcium-dependent lectin activity. It internalizes glycosylated ligands via clathrin-mediated endocytosis and releases them in endosomes. MRC2 Protein, Canine (HEK293, His) is the recombinant canine-derived MRC2 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Mannose receptor C type 2;
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Species
Canine
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Source
HEK293
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Tag
C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
A0A8I3NWU4
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Expression Region
G31-P533
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Protein Length
Partial
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Molecular Weight
60-70 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CD206, also known as the macrophage mannose receptor (MMR), is a type I transmembrane protein primarily expressed on the surface of macrophages and dendritic cells. It plays a critical role in the recognition and uptake of glycoproteins and glycolipids through specific binding to mannose, fucose, and N-acetylglucosamine residues, thus facilitating important immunological processes such as antigen presentation and phagocytosis. Given its pivotal role in immune response and homeostasis, CD206/MMR has garnered significant interest in various fields of biomedical research, including cancer therapy, infectious diseases, and autoimmune disorders. Recent studies have explored its potential as a therapeutic target, considering its differential expression in tumor-associated macrophages compared to normal tissues, making it a promising candidate for targeted drug delivery systems. Additionally, recombinant CD206/MMR protein has been utilized in vaccine development and as a tool for studying macrophage function and polarization. The characterization and manipulation of this receptor could lead to innovative approaches in modulating immune responses and improving therapeutic outcomes in diseases where macrophage function is compromised or dysregulated. Overall, research on CD206/MMR continues to illuminate its crucial role in immunity and offers opportunities for therapeutic advancements.
