Analytical Data
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Gene name
CLEC4F/CLECSF13
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简介
CLEC4F/CLECSF13 protein, a receptor with a distinct affinity for galactose and fucose, suggests involvement in endocytosis. With a binding preference for these carbohydrates, it plays a role in recognizing and potentially internalizing cellular components. CLEC4F/CLECSF13's implication in endocytosis highlights its significance in cellular uptake mechanisms, hinting at potential contributions to various physiological processes. CLEC4F/CLECSF13 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CLEC4F/CLECSF13 protein, expressed by HEK293 , with N-hFc labeled tag.
- Application
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Alternative Names
C-type lectin domain family 4 member F; C-type lectin 13; Kupffer cell receptor; Kclr
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Species
Mouse
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Source
HEK293
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Tag
N-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P70194
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Expression Region
R70-G548
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AA Sequence
RPEWNKEPPSLLLRGSNNSGHDNHSQFVRETEMQVAIQRLRDYEENSSSCHKEVQILKYQMDNVSSLVQLLGSHLEDVNADILQTKDVLKESGALALETQALRSSLEVASADIHSLRGDLEKANAMTSQTRGLLKSSTENTSAELHVLGRGLEEAQSEIQALRGSLQSANDLSSQTQGFLQHSMDNISAQIQTVRDGMERAGEKMNSLKKELETLTAQTQKANGHLEQTDAQIQGLKAELKSTSSLNSRIEVVNGQMKDASRELQTLRRDLSDVSALKSNVQMLQSNLQRAKTEMQTLKADLQATKALTAKIQGEQNRLGALQEAVAAQKQEQKTQNQVLQLIAQNWKYFNGNFYYFSRDKKPWREAEKFCTSQGAHLASVTSQEEQAFLVQTTSSGDHWIGLTDQGTEGIWRWVDGTPFNNAQSKGFWGKNQPDNWRHRNGEREDCVHVRQQWNDMACGSSYPWVCKKSTGWSAARVG
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Protein Length
Extracellular Domain
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Molecular Weight
95-120 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CLEC4F and CLECSF13 are members of the C-type lectin domain family, which play crucial roles in the immune system, particularly in the recognition and binding of pathogens. CLEC4F, primarily expressed in dendritic cells, functions as a pattern recognition receptor that can detect and respond to various microbial components, thereby modulating immune responses. Meanwhile, CLECSF13, often found in macrophages, is implicated in the regulation of inflammation and host defense mechanisms. Research focuses on the structural and functional characterization of these proteins, as their distinct mechanisms of pathogen recognition and immune modulation may reveal new therapeutic targets. Understanding how CLEC4F and CLECSF13 are involved in immune responses could lead to advances in vaccine development and treatment for infectious diseases, allergies, and autoimmune disorders. The expression and signaling pathways associated with these lectins are also being studied to elucidate their roles in both innate and adaptive immunity. This research is critical for developing novel immunotherapeutic strategies, particularly in the context of increasing microbial resistance and the complexity of immune-related diseases.
