Analytical Data
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基因名
CLEC-1
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简介
CLEC-1/CLEC1A proteins belong to the CTL/CTLD superfamily and are known for their diverse functions in cell adhesion, signaling, glycoprotein turnover, inflammation, and immune responses. It is involved in potentially regulating dendritic cell function. CLEC-1/CLEC1A Protein, Rat (HEK293, Fc) is the recombinant rat-derived CLEC-1/CLEC1A protein, expressed by HEK293 , with N-hFc labeled tag.
- Application
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别名
CLEC1A; C-type lectin domain family 1 member A; CLEC1
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种属
Rat
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表达系统
HEK293
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标签
N-hFc
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
D3ZGU3
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表达区间
Q73-Q269
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氨基酸序列
QFYQLSNTQQDSITEKDERLGNMSRQLQSLQTQNRKLTETLQQVAVKLCRELYNKSGGHRCSPCPEKWKWHGNKCYQFYKESKTWQSCEYFCLADNATMLKISTQEELDFAMPQSYSEFFYSYWTGLSRNGSGKAWLWTDGTPYSFELFEIIIDPTNLRSRDCMTIFNGKAYSKDCKELRRCACERVAGRVVPEELQ
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蛋白长度
Partial
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分子量
60-90 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CLEC-1, or C-type lectin domain family 1, has garnered significant attention in recent years due to its roles in immune response and potential therapeutic applications. As a cell surface receptor, CLEC-1 is primarily expressed in dendritic cells and macrophages, where it functions in recognizing specific pathogen-associated molecular patterns (PAMPs). Its interaction with various ligands initiates signaling pathways that modulate innate immune responses, aiding in the recognition of pathogens and the regulation of inflammation. Research has indicated that CLEC-1 plays a crucial role in dendritic cell maturation and cytokine production, influencing adaptive immune responses. Given its vital function in immune regulation, CLEC-1 has been explored as a potential target for vaccines and immunotherapies. Studies have also indicated associations between CLEC-1 activity and various diseases, including infections and autoimmune disorders. The recombinant expression of CLEC-1 protein allows for in-depth studies into its structure-function relationships and the mechanisms underlying its immune regulatory roles. By understanding its biological pathways and interactions, researchers aim to harness CLEC-1 in developing innovative strategies for disease management and therapeutic interventions. Consequently, CLEC-1 represents a promising avenue in immunology research, with implications extending to vaccine development and the treatment of immune-related diseases.
