Analytical Data
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基因名
LRP-12
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简介
LRP-12, a probable receptor, potentially facilitates the internalization of lipophilic molecules and signal transduction. It may function as a tumor suppressor and interacts with proteins RACK1, ZFYVE9, and NMRK2. LRP-12 Protein, Human (HEK293, His) is the recombinant human-derived LRP-12 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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别名
Low-Density Lipoprotein Receptor-Related Protein 12; LRP-12; Suppressor of Tumorigenicity 7 Protein; LRP12; ST7
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q9Y561-1
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表达区间
E33-I488
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氨基酸序列
EHSENVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI
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蛋白长度
Extracellular Domain
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分子量
60-85 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LRP-12 (Low-Density Lipoprotein Receptor-Related Protein 12) is a protein that has garnered attention in the field of molecular biology due to its role in cell signaling and development. As a member of the LDL receptor family, LRP-12 is implicated in various biological processes, including the regulation of lipid metabolism, neuronal function, and immune responses. Its involvement in these processes suggests potential connections to several diseases, such as cancer and neurodegenerative disorders. Research on LRP-12 has primarily focused on its structural characteristics, signaling pathways, and functional implications in cellular contexts. Consequently, the recombinant expression of LRP-12 presents a valuable tool for investigating its physiological roles and developing therapeutic strategies. By using recombinant DNA technology, researchers can produce LRP-12 in controlled laboratory settings, allowing for detailed studies on its interactions with other proteins and its biological effects. Understanding LRP-12 at a molecular level could provide insights into its potential as a biomarker or therapeutic target, emphasizing the importance of continued research in this area to unravel the complexities of LRP-12's functions in health and disease.
