Analytical Data
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Gene name
Caspase-1/CASP1 p20
- Application
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Alternative Names
ICE; IL1BC; IL1-BC; P45; Interleukin 1 Beta Converting Enzyme; Apoptosis-Related Cysteine Peptidase; Interleukin-1 beta convertase
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Species
Pig
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q9N2I1
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Expression Region
Asn120~Asp297
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Molecular Weight
21kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Caspase-1 (CASP1) is a crucial enzyme that plays a significant role in the regulation of programmed cell death and the inflammatory response. It is a part of the apoptosome complex and is primarily known for its function in the maturation and secretion of pro-inflammatory cytokines such as IL-1β and IL-18. The p20 subunit of Caspase-1, generated by its proteolytic cleavage, is essential for its enzymatic activity and stability, making it a significant focus of research. Dysregulation of Caspase-1 has been implicated in various inflammatory diseases, autoimmune disorders, and metabolic syndromes, highlighting its potential as a therapeutic target. Recombinant Caspase-1 p20 protein is utilized in numerous studies to dissect its molecular mechanisms, interactions, and regulatory pathways, aiding in the understanding of inflammation and cell death processes. Investigating this protein can contribute to the development of novel treatments for diseases associated with the dysregulation of Caspase-1, fostering advances in therapeutic interventions by targeting this pivotal enzyme in the inflammatory cascade.
