Analytical Data
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Gene name
IL-27R alpha
- Application
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Alternative Names
CRL1; IL27R; TCCR; WSX1; Zcytor1; T-Cell Cytokine Receptor Type 1; Cytokine receptor-like 1; Type I T-cell cytokine receptor
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
> 97% as determined by SDS-PAGE.
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Uniprot
Q6UWB1
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Expression Region
Glu123~Pro343
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Molecular Weight
28kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Interleukin-27 receptor alpha (IL-27Rα), also known as WSX-1, is a critical component of the IL-27 receptor complex, which plays a vital role in regulating immune responses, particularly in T cell differentiation and activation. The significance of IL-27Rα has gained attention due to its involvement in various pathological conditions, including autoimmune diseases, infectious diseases, and cancer. IL-27, a member of the IL-6/IL-12 cytokine family, is produced primarily by antigen-presenting cells and has been shown to exert both pro-inflammatory and anti-inflammatory effects. Research has demonstrated that IL-27Rα signaling can influence the balance between Th1 and Th2 cells, thereby impacting overall immune responses. The recombinant expression of IL-27Rα protein allows researchers to investigate its functional properties, signaling pathways, and interactions with other cytokines. Understanding the role of IL-27Rα may provide insights into therapeutic interventions targeting immune-related disorders. This research area holds promise for developing novel treatments that modulate immune responses, enhancing anti-tumor immunity or alleviating autoimmune disorders. As such, IL-27Rα not only represents a critical biomarker for immune modulation but also serves as a potential target for the design of innovative immunotherapeutic strategies.
