Recombinant Human Beta-glucuronidase/GUSB Protein，His

Beta-glucuronidase (GUSB) is an important lysosomal enzyme responsible for the hydrolysis of glucuronides, which are conjugates formed by the attachment of glucuronic acid to various substances, including drugs and endogenous metabolites. Deficiency of GUSB leads to the lysosomal storage disorder known as mucopolysaccharidosis type VII (MPS VII), characterized by the accumulation of glycosaminoglycans in lysosomes, resulting in various clinical manifestations ranging from skeletal abnormalities to neurological impairment. The study of recombinant GUSB has gained significant attention as a potential therapeutic approach for MPS VII. By utilizing techniques such as recombinant DNA technology, researchers can produce functional GUSB in various expression systems, including yeast, bacteria, and mammalian cells. This production not only enhances our understanding of the enzyme's structure and function but also facilitates the development of enzyme replacement therapies (ERT) aimed at restoring GUSB levels in affected individuals. Additionally, the investigation of GUSB has broader implications in pharmacology and toxicology, as it plays a critical role in drug metabolism and clearance. The continued research on GUSB and recombinant protein production not only holds promise for treating MPS VII but also contributes to the growing field of enzyme-based therapies for a range of metabolic disorders.