Analytical Data
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基因名
Claudin-6/CLDN6 Protein-VLP
- Application
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别名
Claudin-6; Skullin; CLDN6; Claudin6; Skullin 5
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P56747
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表达区间
1-82aa
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分子量
24.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Claudin-6 (CLDN6) is a member of the claudin family of proteins, which are integral components of tight junctions, playing a critical role in maintaining epithelial barrier integrity. Its expression is particularly notable in various types of cancers, making it a promising target for therapeutic interventions. The development of vaccine-like constructs using virus-like particles (VLPs) presenting CLDN6 has emerged as a novel strategy for cancer immunotherapy. VLPs mimic the structure of viruses but lack viral genetic material, making them safe and effective carriers for antigens. By incorporating CLDN6 into VLPs, researchers aim to elicit a robust immune response that specifically targets cancer cells expressing this protein. This approach not only enhances immune recognition but also improves the stability and delivery of the antigen. The ongoing studies focus on optimizing the VLP-CLDN6 constructs to evaluate their immunogenicity and potential for inducing protective T cell responses against tumors. Such advancements in the field of cancer immunotherapy highlight the significance of CLDN6 as a target for innovative treatment strategies, paving the way for the development of effective vaccines capable of combating cancers that express this protein.
