Analytical Data
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基因名
IL-15
- Application
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别名
Interleukin-15; IL-15; IL15
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种属
Rat
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表达系统
E. coli
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标签
Tag Free
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纯度
> 90% as determined by SDS-PAGE.
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蛋白编号
P97604
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表达区间
N49-S162
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分子量
13.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-15 (IL-15) is a pivotal cytokine that plays a crucial role in the immune system, particularly in the proliferation and activation of natural killer (NK) cells and memory T cells. Research into recombinant IL-15 has gained significant attention due to its potential therapeutic applications in cancer treatment, infectious diseases, and immune deficiencies. Unlike IL-2, IL-15 does not induce lymphocyte apoptosis, allowing for prolonged cellular survival and enhanced immune responses. The ability to produce recombinant IL-15 has enabled scientists to explore its function in various immunotherapeutic strategies, such as enhancing anti-tumor immunity and boosting responses to vaccines. Additionally, studies have shown that IL-15 can enhance the efficacy of adoptive cell transfer therapies, making it a promising candidate for combination therapies aimed at improving patient outcomes. Advances in recombinant DNA technology have facilitated the generation of stable IL-15-producing cell lines and optimized production protocols, making large-scale production feasible. Ongoing research is focused on elucidating the mechanisms of IL-15 signaling, its interactions with other cytokines, and its role in different pathological contexts, which could pave the way for innovative treatments harnessing the power of this cytokine. Overall, the study of recombinant IL-15 is a dynamic field that holds great promise for enhancing immune responses in various therapeutic settings.
