Analytical Data
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基因名
CD26/Dipeptidyl Peptidase 4
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简介
CD26/Dipeptidyl Peptidase 4 Protein is a serine membrane anchored exopeptidase, belonging to dipeptidyl peptidase (DPP) family. CD26/Dipeptidyl Peptidase 4 Protein is widely expressed in a variety of tissues and many cells[1]. CD26/Dipeptidyl Peptidase 4 Protein, Cynomolgus (HEK293) is the recombinant cynomolgus-derived CD26/Dipeptidyl Peptidase 4 protein, expressed by HEK293 , with tag free.
- Application
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别名
Dipeptidyl peptidase 4; ADABP; ADCP-2; DPP IV; TP103; CD26; DPP4
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种属
Cynomolgus
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表达系统
HEK293
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
F6VRB0
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表达区间
D34-P766
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蛋白长度
Partial
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分子量
92-102 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD26, also known as Dipeptidyl Peptidase 4 (DPP-4), is a multifunctional type II transmembrane glycoprotein that plays a crucial role in glucose metabolism, immune regulation, and various physiological processes. It cleaves dipeptides from the N-terminus of peptides, including incretins such as GLP-1 (glucagon-like peptide-1), which are essential for insulin secretion in response to food intake. Elevated CD26/DPP-4 levels have been associated with metabolic disorders, particularly type 2 diabetes, making it a key target for therapeutic intervention. DPP-4 inhibitors have been developed as antidiabetic medications, highlighting the enzyme's importance in glucose homeostasis. Furthermore, CD26 is also involved in T-cell co-stimulation and the modulation of immune responses, linking its activity to autoimmune diseases and cancer. As a result, the study of recombinant CD26/DPP-4 proteins has garnered significant interest, aiming to better understand its biological functions, develop novel inhibitors, and explore its potential as a biomarker for various diseases. Characterizing recombinant CD26/DPP-4 can aid in elucidating the molecular mechanisms underlying its diverse roles in health and disease, paving the way for the development of targeted therapies and improving the management of metabolic and immune-related conditions.
