Analytical Data
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基因名
KIR2DL1
- Application
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别名
CD158A; Cl-42; NKAT1; Killer Cell Immunoglobulin Like Receptor Two Domains, Long Cytoplasmic Tail,1; Natural killer-associated transcript 1; MHC class I NK cell receptor
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P43626
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表达区间
His22~His245
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分子量
28kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KIR2DL1, a member of the killer immunoglobulin-like receptor (KIR) family, plays a crucial role in the regulation of natural killer (NK) cell activity and contributes significantly to the immune response against viral infections and tumor cells. Its specific interaction with HLA-C molecules, particularly those encoding the C1 and C2 epitopes, mediates inhibitory signals that prevent the inappropriate activation of NK cells, thereby maintaining immune tolerance and self-recognition. The study of KIR2DL1 recombinant proteins is critical for understanding the mechanisms of NK cell regulation and how variations in KIR genes can influence susceptibility to diseases, including cancer and autoimmune disorders. By generating and characterizing KIR2DL1 recombinant proteins, researchers aim to elucidate the receptor's structural properties, ligand interactions, and signaling pathways. This knowledge not only sheds light on basic immunological processes but also has potential therapeutic implications, such as enhancing NK cell responses in cancer immunotherapy or designing novel immunomodulatory strategies. Moreover, the investigation of KIR2DL1 polymorphisms in different populations can provide insights into the evolutionary pressures shaping the immune system and inform personalized medicine approaches. Overall, the research surrounding KIR2DL1 recombinant proteins is pivotal in advancing our understanding of innate immunity and its clinical applications.
