Analytical Data
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Gene name
KEL/Kelch-like
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简介
KEL/Kelch-like protein 41 acts as a zinc endopeptidase with a distinct endothelin-3-converting enzyme function. It selectively cleaves endothelin-1 (EDN1), endothelin-2 (EDN2), and endothelin-3 (EDN3), displaying a preference for EDN3. KEL's endopeptidase activity plays a pivotal role in processing endothelin peptides, emphasizing its involvement in the modulation of endothelin signaling pathways. KEL/Kelch-like protein 41 Protein, Human (HEK293, His, solution) is the recombinant human-derived KEL/Kelch-like protein 41 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Alternative Names
rHuKell blood group glycoprotein/KEL, His; Kell blood group glycoprotein; CD238; KEL
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P23276
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Expression Region
N68-W732
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AA Sequence
NFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETNNSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQEQKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLACDNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDSHDTHSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW
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Protein Length
Extracellular Domain
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Molecular Weight
85-120 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Kelch-like proteins, primarily characterized by the presence of Kelch motifs, play critical roles in various biological processes, including cell signaling, cytoskeletal organization, and the regulation of gene expression. Their unique structure allows them to form diverse protein complexes by interacting with different partners, which highlights their significance in cellular functions and responses to stress. Research has increasingly focused on the role of Kelch-like proteins in disease mechanisms, particularly in cancer and neurodegenerative disorders. For instance, aberrations in the expression or function of these proteins are often linked to tumor progression and metastasis, as they can influence pathways related to cell proliferation and apoptosis. Additionally, some Kelch-like proteins are recognized as potential biomarkers for disease diagnosis and prognosis, thus presenting promising avenues for therapeutic intervention. Furthermore, the advent of advanced genomic and proteomic technologies has enhanced our understanding of their complex interactions and regulatory networks, paving the way for innovative strategies to target these proteins in disease contexts. Overall, the study of Kelch-like proteins holds substantial promise for elucidating fundamental biological processes and developing novel therapeutic approaches.
