Analytical Data
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基因名
IL-9
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简介
IL-9 Protein, Mouse (CHO), derived from CHO cell, is a member of the TH2 cytokine family.IL-9 Protein, Mouse (CHO, His) has recently been implicated as an essential factor in determining mucosal immunity and susceptibility to atopic asthma.
- Application
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生物活性
Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. The ED50 for this effect is 3.339 ng/mL, corresponding to a specific activity is 3.0×105 units/mg. Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. The ED50 for this effect is 3.339 ng/mL, corresponding to a specific activity is 3.0×105 units/mg.
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别名
rMuIL-9; Cytokine P40; T-cell Growth Factor P40
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种属
Mouse
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表达系统
CHO
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标签
C-6*His
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纯度
> 90% as determined by SDS-PAGE.
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蛋白编号
P15247
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表达区间
Q19-P144
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蛋白长度
Full Length of Mature Protein
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分子量
28-42 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-9 (IL-9) is a cytokine mainly produced by T-helper 2 cells and is known for its role in promoting inflammation and modulating immune responses. Research into IL-9 has gained momentum due to its involvement in various allergic and inflammatory diseases, including asthma, atopic dermatitis, and rheumatoid arthritis. IL-9 operates through the IL-9 receptor (IL-9R), influencing a range of immune cells, such as mast cells, eosinophils, and T cells, thereby enhancing the production of other cytokines and contributing to the pathophysiology of allergic reactions. As a result, IL-9 and its signaling pathway have become potential therapeutic targets for treating allergic diseases and other immune disorders. The production of recombinant IL-9 protein has enabled researchers to investigate its biological functions, mechanisms of action, and the development of IL-9 antagonists or therapies that could ameliorate the effects of excessive IL-9 signaling. Current studies focus on exploring how IL-9 and its receptor interact with various immune cells, the molecular pathways involved in IL-9-mediated inflammation, and the potential of utilizing recombinant IL-9 or its inhibitors in clinical settings. This research not only aims to deepen the understanding of IL-9's role in immune regulation but also to pave the way for innovative treatments that can alleviate the burden of chronic inflammatory diseases associated with IL-9 dysregulation.
