Analytical Data
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Gene name
CD42b/GP1BA
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简介
CD42b/GP1BA protein is an important platelet membrane protein that interacts with the A1 domain of von Willebrand factor and contributes to the formation of subendothelial platelet plugs. Its GP1BA subunit forms a disulfide-linked complex with two GP1BB subunits, collectively called GP-Ib. CD42b/GP1BA Protein, Human (HEK293, His) is the recombinant human-derived CD42b/GP1BA protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
GP-Ib alpha; GPIb-alpha; GPIbA; GP1BA; BDPLT1; BDPLT3; BSS; CD42B; CD42b-alpha; DBPLT3; GP1B; VWDP; BP1BA; MGC34595
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Species
Human
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Source
HEK293
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Tag
C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P07359
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Expression Region
H17-L531
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AA Sequence
HPICEVSKVASHLEVNCDKRNLTALPPDLPKDTTILHLSENLLYTFSLATLMPYTRLTQLNLDRCELTKLQVDGTLPVLGTLDLSHNQLQSLPLLGQTLPALTVLDVSFNRLTSLPLGALRGLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLANNNLTELPAGLLNGLENLDTLLLQENSLYTIPKGFFGSHLLPFAFLHGNPWLCNCEILYFRRWLQDNAENVYVWKQGVDVKAMTSNVASVQCDNSDKFPVYKYPGKGCPTLGDEGDTDLYDYYPEEDTEGDKVRATRTVVKFPTKAHTTPWGLFYSWSTASLDSQMPSSLHPTQESTKEQTTFPPRWTPNFTLHMESITFSKTPKSTTEPTPSPTTSEPVPEPAPNMTTLEPTPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTPIPTIATSPTILVSATSLITPKSTFLTTTKPVSLLESTKKTIPELDQPPKLRGVLQGHLESSRNDPFLHPDFCCLLPL
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Protein Length
Extracellular Domain
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Molecular Weight
100-130 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CD42b, also known as glycoprotein Ib alpha (GP1BA), is a critical component of the platelet membrane receptor complex involved in hemostasis and thrombosis. Functioning as a primary receptor for von Willebrand factor (vWF), CD42b/GP1BA plays an essential role in platelet adhesion to sites of vascular injury, which is crucial for the formation of a stable blood clot. Abnormalities in this receptor can lead to bleeding disorders, such as Bernard-Soulier syndrome, characterized by impaired platelet function due to defective GP1BA expression. The recombinant protein of CD42b/GP1BA has garnered significant interest for its potential applications in both research and clinical settings. Studying this protein enhances our understanding of platelet biology and the molecular mechanisms underlying thrombosis and hemostasis. Furthermore, the recombinant form allows for the investigation of therapeutic strategies aimed at modulating platelet function in various hematological conditions. By creating a reliable source of CD42b/GP1BA, researchers can generate specific antibodies, screen for inhibitors, and develop diagnostic tools that can aid in the management of clotting disorders. Overall, the research surrounding CD42b/GP1BA recombinant protein addresses fundamental questions in vascular biology, while also offering promising avenues for therapeutic intervention in thrombotic and hemorrhagic diseases.
