Analytical Data
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Gene name
CD5L
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简介
The CD5L protein is primarily expressed by macrophages and regulates inflammatory responses in infection or atherosclerosis. CD5L is incorporated into adipocytes via CD36-mediated endocytosis, thereby inhibiting lipid droplet size and affecting lipolysis. CD5L Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD5L protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Alternative Names
CD5 antigen-like; mAIM; SP-alpha; Cd5l; AIM; API6
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Species
Mouse
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9QWK4
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Expression Region
E22-V352
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AA Sequence
ESPTKVQLVGGAHRCEGRVEVEHNGQWGTVCDDGWDRRDVAVVCRELNCGAVIQTPRGASYQPPASEQRVLIQGVDCNGTEDTLAQCELNYDVFDCSHEEDAGAQCENPDSDLLFIPEDVRLVDGPGHCQGRVEVLHQSQWSTVCKAGWNLQVSKVVCRQLGCGRALLTYGSCNKNTQGKGPIWMGKMSCSGQEANLRSCLLSRLENNCTHGEDTWMECEDPFELKLVGGDTPCSGRLEVLHKGSWGSVCDDNWGEKEDQVVCKQLGCGKSLHPSPKTRKIYGPGAGRIWLDDVNCSGKEQSLEFCRHRLWGYHDCTHKEDVEVICTDFDV
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Protein Length
Full Length of Mature Protein
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Molecular Weight
43-55 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD5L (CD5 molecule-like) is a multifunctional protein that plays a crucial role in the immune system, particularly in regulating cell survival and apoptosis in immune cells. Its involvement in various immune responses has garnered attention in recent years, especially concerning its potential implications in autoimmune diseases and cancer. CD5L is known to interact with key immune pathways, influencing the activation and differentiation of T and B lymphocytes. Researchers have been focusing on the recombinant expression of CD5L to investigate its biological functions further and to explore potential therapeutic applications. Recombinant CD5L proteins can be utilized in various assays to elucidate its mechanism of action and interactions with other immune modulators. Moreover, studying CD5L's structure-function relationship through recombinant technology allows for the development of specific inhibitors or agonists that could potentially modulate immune responses in disease settings. Overall, the investigation of CD5L recombinant proteins holds promise for advancing our understanding of immune regulation and discovering novel therapeutic strategies for treating immune-related conditions.
