Analytical Data
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基因名
IL6R
- Application
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别名
CD126; gp80; IL6R; IL-6R-1; IL-6R-Alpha; IL6RA; IL-6 receptor subunit alpha; Membrane glycoprotein 80
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种属
Rat
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表达系统
E. coli
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标签
N-His
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纯度
> 95% as determined by SDS-PAGE.
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蛋白编号
P22273
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表达区间
Leu385~Arg462
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分子量
13kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-6 receptor (IL6R) is a crucial component of the interleukin-6 (IL-6) signaling pathway, which plays a significant role in various physiological processes, including immune response, inflammation, and hematopoiesis. Dysregulation of IL-6 signaling has been implicated in numerous pathological conditions, such as autoimmune diseases, chronic inflammatory disorders, and malignancies. The recombinant IL6R protein has become a focal point for research due to its potential therapeutic applications. By producing and characterizing IL6R in a recombinant form, scientists aim to study its structure-function relationship and understand the molecular mechanisms underpinning IL-6 signaling. Moreover, recombinant IL6R can serve as a valuable tool for therapeutic interventions, such as blocking IL-6 activity in conditions like rheumatoid arthritis or certain cancers. Recent advancements in biotechnology have facilitated the production of high-purity recombinant IL6R, enabling detailed studies on its interactions with IL-6 and its role in cell signaling pathways. This research not only enhances our understanding of IL-6 mediated signaling but also paves the way for the development of novel therapeutic strategies targeting IL-6/IL6R interactions in various diseases. Overall, the study of IL6R recombinant protein is vital for unlocking new avenues in treating disorders associated with aberrant IL-6 signaling.
