Analytical Data
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Gene name
CD1D
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简介
CD1D protein, in partnership with B2M, functions as an antigen-presenting protein, binding self and non-self glycolipids. It presents these molecules to T-cell receptors on natural killer T-cells, playing a pivotal role in immune responses. CD1D also interacts with MHC II and CD74, contributing to the coordination of the adaptive immune system. CD1D Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD1D protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Antigen-presenting glycoprotein CD1d; CD1D; R3G1
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Species
Mouse
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P11609
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Expression Region
M1-G305
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Protein Length
Extracellular Domain
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Molecular Weight
45-50 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD1d is a member of the CD1 family of glycoproteins, which play a crucial role in the presentation of lipid antigens to T cells, particularly natural killer T (NKT) cells. Research on CD1d has gained significant attention due to its involvement in immune responses, autoimmune diseases, and cancer immunotherapy. Unlike classical Major Histocompatibility Complex (MHC) molecules, CD1d presents lipid-based antigens, which are essential for the activation of NKT cells that bridge the innate and adaptive immune systems. Understanding the structure and function of recombinant CD1d protein is vital for elucidating its mechanism in antigen presentation and its role in various immune-mediated disorders. Advances in recombinant DNA technology have enabled the production of CD1d proteins, facilitating detailed studies on their interaction with lipid ligands and NKT cells. This research not only enhances our knowledge of immune regulation but also holds potential for developing new therapeutic strategies aimed at manipulating the immune response for better disease management. Overall, the investigation of recombinant CD1d protein represents a promising avenue in immunology, with implications for vaccine development and cancer therapy.
