Analytical Data
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基因名
CD1D-B2M Heterodimer
- Application
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别名
R3G1; CD1d
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P15813
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表达区间
20-301aa
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分子量
47.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The CD1D-B2M heterodimer is a crucial component of the immune system, primarily involved in the presentation of lipid antigens to T cells. CD1D, a member of the CD1 family of glycoproteins, is responsible for the recognition of glycolipids and is expressed on various immune cells, including dendritic cells and B cells. β2-microglobulin (B2M) is an essential protein that stabilizes the structure of CD1D, enabling its function in antigen presentation. Research on the CD1D-B2M heterodimer has garnered significant interest due to its role in facilitating the activation of NKT (natural killer T) cells, which are pivotal in bridging innate and adaptive immunity. Studies have shown that these cells play a vital role in various immune responses, including tumor surveillance and the regulation of autoimmune diseases. Understanding the structural and functional dynamics of the CD1D-B2M heterodimer can provide insights into its involvement in immune regulation and disease mechanisms. Recent advances in recombinant protein technology have enabled the production and study of this heterodimer, paving the way for potential therapeutic applications, including vaccine development and immunotherapy. By exploring the interactions and functionalities of this complex, researchers aim to leverage its properties for innovative approaches in treating infectious diseases, cancer, and autoimmune disorders. The investigation of CD1D-B2M not only enhances our understanding of lipid antigen presentation but also opens new avenues for harnessing the immune system in clinical settings.
