Analytical Data
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基因名
CD1A-B2M Heterodimer
- Application
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别名
CD1-A; CD1; FCB6; HTA1; R4; T6; T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P06126
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表达区间
Asn17~Val300
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分子量
35&28kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The CD1C-B2M heterodimer is a key component in the immune system, playing a crucial role in the presentation of lipid antigens to T cells. CD1C, a member of the CD1 family, is responsible for presenting glycolipid antigens derived from various sources, including pathogens and self-lipids, to invariant natural killer T (iNKT) cells. The heterodimerization with β2-microglobulin (B2M) is essential for the proper folding, stability, and surface expression of the CD1C molecule. Understanding the structure and function of the CD1C-B2M heterodimer is vital for elucidating its role in immune responses and potential applications in immunotherapy. Recombinant protein studies have enabled the exploration of this heterodimer's antigen presentation capabilities, providing insights into its interactions with T cell receptors. This research holds promise for developing novel therapeutic strategies targeting lipid antigens in various diseases, including cancer and infectious diseases, thereby enhancing our understanding of the complexities of immune recognition and response.
