Recombinant Human CD117/c-Kit Protein(HEK293), Avi & His

CD117, also known as c-Kit, is a receptor tyrosine kinase that plays a crucial role in various biological processes, including cell survival, proliferation, and differentiation. It is predominantly expressed in hematopoietic stem cells, mast cells, and interstitial cells of Cajal, making it vital for normal physiological functions such as hematopoiesis and gastrointestinal motility. The study of CD117/c-Kit has significant implications in cancer research, particularly in understanding its mutation-driven malignancies like gastrointestinal stromal tumors (GISTs), where activating mutations lead to uncontrolled cell growth. Moreover, c-Kit is implicated in other cancer types, including melanoma and certain leukemias, highlighting its potential as a therapeutic target. Researchers have been focusing on developing recombinant proteins for c-Kit to elucidate its signaling pathways and investigate novel therapeutic strategies. These recombinant proteins can be utilized in assays to study interactions with downstream signaling molecules, assess the efficacy of small molecule inhibitors, and screen for c-Kit activating antibodies. Furthermore, elucidating the structure-function relationship of c-Kit through recombinant protein studies can aid in the design of more selective therapeutics aimed at targeting aberrant c-Kit signaling in cancer. Overall, the exploration of CD117/c-Kit recombinant proteins serves as a critical research avenue for advancing the understanding of its biological functions and developing targeted therapies for diseases associated with c-Kit dysregulation.