Analytical Data
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基因名
(CD44)
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简介
The CD44 protein binds to hyaluronic acid and TGF-β receptors and contributes to cytokine function. CD44 is involved in T cell activation, protein phosphorylation, and Wnt signaling and is strategically located in the plasma membrane and microvilli. CD44 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD44 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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生物活性
Measured by its binding ability in a functional ELISA. When rmCD44 is present at 1 μg/mL, the concentration of biotinylated hyaluronan that produces 50% of the optimal binding response is found to be approximately 17.45 ng/mL. Measured by its binding ability in a functional ELISA.When rmCD44 is present at 1 μg/mL, the concentration of biotinylated hyaluronan that produces 50% of the optimal binding response is found to be approximately 17.45 ng/mL.
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别名
CD44 antigen; CDw44; Epican; ECMR-III; CD44; LHR; MDU2
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种属
Mouse
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
NP_001034240.1
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表达区间
Q25-T224
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氨基酸序列
QIDLNVTCRYAGVFHVEKNGRYSISRTEAADLCQAFNSTLPTMDQMKLALSKGFETCRYGFIEGNVVIPRIHPNAICAANHTGVYILVTSNTSHYDTYCFNASAPPEEDCTSVTDLPNSFDGPVTITIVNRDGTRYSKKGEYRTHQEDIDASNIIDDDVSSGSTIEKSTPESYILHTYLPTEQPTGDQDDSFFIRSTLAT
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蛋白长度
Partial
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分子量
37 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD44 is a cell surface glycoprotein that plays a crucial role in cell-cell interactions, cell adhesion, and migration. It is primarily recognized for its involvement in the immune response and is expressed on various cell types, including lymphocytes, fibroblasts, and epithelial cells. CD44 exists in multiple isoforms generated by alternative splicing, which contributes to its diverse biological functions. Research has shown that CD44 is implicated in various pathological conditions, including cancer metastasis, inflammation, and tissue repair. Due to its significant role in these processes, CD44 has emerged as a potential therapeutic target. Recombinant CD44 protein has been produced to facilitate detailed studies on its structure-function relationships and to explore its role in disease mechanisms. By generating recombinant CD44, researchers aim to better understand its interactions with hyaluronic acid and other ligands, which can provide insights into its role in tumor progression and inflammatory responses. The availability of recombinant CD44 also opens avenues for the development of novel diagnostic and therapeutic strategies, including targeted drug delivery systems and immunotherapies. Overall, the investigation of recombinant CD44 proteins presents an exciting research frontier that holds promise for advancing our understanding of CD44's multifaceted roles in health and disease.
