Analytical Data
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Gene name
Siglec-5
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简介
Siglec-F Protein, a putative adhesion molecule, crucially mediates sialic-acid dependent binding to cells with a preferential affinity for alpha-2,3-linked sialic acid. Notably, its sialic acid recognition site may be concealed through cis interactions with sialic acids on the same cell surface. Siglec-5 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Siglec-5 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
CD170; CD33 antigen-like 2; CD33L2; OBBP2; Siglec5; SIGLEC5; OB-BP2
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Species
Mouse
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Source
HEK293
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Tag
C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q920G3
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Expression Region
T17-L439
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Protein Length
Extracellular Domain
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Molecular Weight
65-68 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Siglec-5 is a member of the sialic acid-binding immunoglobulin-like lectins (Siglecs) family, which play crucial roles in cell signaling and immune regulation. Research has shown that Siglec-5 is predominantly expressed on immune cells, such as monocytes and macrophages, and is involved in modulating immune responses, particularly in the context of inflammation and pathogen recognition. Understanding the function and mechanisms of Siglec-5 is critical for elucidating its role in various immunological disorders, including autoimmune diseases and infections. Recent studies have indicated that Siglec-5 can interact with sialylated glycoproteins, affecting cellular communication and immune evasion strategies employed by pathogens. Furthermore, the development of recombinant Siglec-5 proteins allows for in-depth exploration of its biological activity and could aid in the development of novel therapeutic strategies aimed at targeting specific immune pathways. Enhanced knowledge of Siglec-5 interactions and signaling pathways may reveal potential implications for treating diseases characterized by immune dysregulation. Overall, ongoing research involving Siglec-5 recombinant proteins is pivotal for advancing our understanding of immune regulation and discovering new avenues for clinical interventions.
