Analytical Data
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Gene name
FGFR-2
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简介
FGFR2, also known as CD332 (differentiated cluster 332), is a receptor for fibroblast growth factor. FGFR2 is involved in activation of RAS, MAPK1/ERK2, MAPK3/ERK1, MAP kinase signaling pathways, and AKT1 signaling pathways. FGFR2 up-regulates PAI-1 via JAK2/STAT3 signaling and induces M2 polarization in colorectal cancer macrophages. FGFR-2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived FGFR-2 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK
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Species
Mouse
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
E9Q5C3
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Expression Region
R22-E263
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Protein Length
Partial
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Molecular Weight
89.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Fibroblast Growth Factor Receptor 2 (FGFR-2) is a critical member of the FGFR family, which plays a vital role in various physiological processes, including cell proliferation, differentiation, and tissue repair. Abnormal FGFR-2 signaling has been implicated in several diseases, particularly various forms of cancer and congenital disorders. The understanding of FGFR-2 functions has spurred significant interest in its potential as a therapeutic target. Research has shown that FGFR-2 is involved in pathways that regulate angiogenesis and epithelial-mesenchymal transition, making it a significant player in tumor progression and metastasis. The development of FGFR-2 recombinant proteins has become a focus in biomedical research, facilitating the study of receptor interactions, signaling mechanisms, and the evaluation of potential inhibitors. Recombinant FGFR-2 proteins serve as valuable tools for drug discovery and the development of targeted therapies, allowing for the exploration of FGFR-2's role in disease mechanisms. As researchers continue to unveil the complexities of FGFR-2 signaling, the insights gained may lead to innovative treatments and improved clinical outcomes for patients suffering from FGFR-2-related pathologies.
