Analytical Data
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Gene name
FGFR-2 beta (IIIc)
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简介
The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 beta (IIIc) Protein, Human (HEK293, Fc) is the recombinant human-derived FGFR-2 beta IIIc protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
Fibroblast growth factor receptor 2; FGFR-2; FGF R2a; FGFR2 alpha
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P21802-1
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Expression Region
R152-E377
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AA Sequence
RAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLE
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Protein Length
Partial
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Molecular Weight
72-95 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Fibroblast Growth Factor Receptor 2 (FGFR-2) is a key member of the fibroblast growth factor receptor family, which plays a critical role in various biological processes including cell proliferation, differentiation, and survival. FGFR-2 exists in multiple isoforms, among which FGFR-2b and FGFR-2c are noteworthy for their distinct functional roles in different tissues. The FGFR-2 beta (IIIc) isoform is primarily associated with pathways involved in developmental biology and tumorigenesis. Abnormal FGFR signaling has been implicated in various cancers, making FGFR-2c a potential therapeutic target. Research into FGFR-2c, particularly through the development of recombinant proteins, has become increasingly important for understanding its structure-function relationship and potential therapeutic applications. Recombinant FGFR-2c proteins allow for the investigation of interaction with specific ligands, elucidation of downstream signaling pathways, and the screening of small molecules that could inhibit aberrant FGFR-2 activity in cancer. This research can contribute to the development of targeted therapies for conditions associated with FGFR-2 dysregulation, providing insights into patient-specific treatment strategies and advancing our understanding of tumor biology. Moreover, the exploration of FGFR-2c can pave the way for biomarker discovery and the development of diagnostic tools, enhancing our ability to identify patients who may benefit from FGFR-targeted therapies. Overall, the study of FGFR-2 beta (IIIc) recombinant proteins is a promising area of research with potential implications for cancer treatment and understanding cellular signaling mechanisms.
