Analytical Data
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Gene name
CD94
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简介
CD94 protein is a key immune receptor for self-non-self discrimination. It forms a complex with KLRC1 or KLRC2 on lymphocyte subsets and recognizes HLA-E loaded with self-peptides. It allows cytotoxic cells to monitor MHC class I expression and promote self-tolerance. CD94 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD94 protein, expressed by HEK293 , with N-His, N-Avi labeled tag.
- Application
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Alternative Names
CD94; KLRD1; KP43; NK cell receptor
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Species
Human
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Source
HEK293
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Tag
N-Avi;N-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13241-1
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Expression Region
S34-I179
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Protein Length
Extracellular Domain
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Molecular Weight
35-45 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD94 is a member of the C-type lectin-like family of receptors that plays a crucial role in the immune response, particularly in the regulation of natural killer (NK) cell activity. It forms heterodimers with NKG2A, NKG2C, or NKG2E receptors, influencing the activation and inhibition of NK cells during immune responses against tumors and viral infections. The study of recombinant CD94 proteins is significant because they can serve as valuable tools for understanding the molecular mechanisms of immune regulation and for developing therapeutic strategies, such as cancer immunotherapies. By producing and characterizing these recombinant proteins, researchers can investigate their interactions with ligands and other immune system components, assess their role in immune signaling pathways, and explore their potential as targets for immune modulation. Furthermore, the ability to generate CD94-based fusion proteins adds an additional layer of functionality, enabling the development of innovative immunotherapeutic agents that can enhance NK cell activity or block inhibitory signals in tumor microenvironments. Overall, research on CD94 recombinant proteins holds promise for advancing our understanding of immune regulation and improving the efficacy of treatments for various diseases, including cancers and chronic infections.
