Analytical Data
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基因名
CD94
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简介
CD94 protein is a key immune receptor for self-non-self discrimination. It forms a complex with KLRC1 or KLRC2 on lymphocyte subsets and recognizes HLA-E loaded with self-peptides. It allows cytotoxic cells to monitor MHC class I expression and promote self-tolerance. CD94 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD94 protein, expressed by HEK293 , with N-His, N-Avi labeled tag.
- Application
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别名
CD94; KLRD1; KP43; NK cell receptor
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种属
Human
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表达系统
HEK293
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标签
N-Avi;N-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13241-1
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表达区间
S34-I179
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蛋白长度
Extracellular Domain
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分子量
35-45 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD94 is a member of the C-type lectin-like family of receptors that plays a crucial role in the immune response, particularly in the regulation of natural killer (NK) cell activity. It forms heterodimers with NKG2A, NKG2C, or NKG2E receptors, influencing the activation and inhibition of NK cells during immune responses against tumors and viral infections. The study of recombinant CD94 proteins is significant because they can serve as valuable tools for understanding the molecular mechanisms of immune regulation and for developing therapeutic strategies, such as cancer immunotherapies. By producing and characterizing these recombinant proteins, researchers can investigate their interactions with ligands and other immune system components, assess their role in immune signaling pathways, and explore their potential as targets for immune modulation. Furthermore, the ability to generate CD94-based fusion proteins adds an additional layer of functionality, enabling the development of innovative immunotherapeutic agents that can enhance NK cell activity or block inhibitory signals in tumor microenvironments. Overall, research on CD94 recombinant proteins holds promise for advancing our understanding of immune regulation and improving the efficacy of treatments for various diseases, including cancers and chronic infections.
