Analytical Data
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基因名
FGFR-2 beta (IIIb)
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简介
The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 beta (IIIb) Protein, Human (HEK293, His) is the recombinant human-derived FGFR-2 beta IIIb protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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别名
BFR-1; FGFR2IIIb; KGFR; CD332; FGF R2b; FGFR2 beta; FGFR2; FGFR2b; Fibroblast growth factor receptor 2 (IIIb)
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P21802-3
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表达区间
R152-E378
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氨基酸序列
RAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLE
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蛋白长度
Partial
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分子量
40-70 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FGFR-2 beta (IIIb), a member of the fibroblast growth factor receptor (FGFR) family, has garnered significant interest due to its critical role in various physiological and pathological processes, including embryonic development, tissue repair, and tumorigenesis. FGFRs, particularly FGFR-2, are known to be involved in signaling pathways that regulate cell proliferation, differentiation, and survival. The beta (IIIb) isoform of FGFR-2 is particularly relevant in the context of cancer, as it is often found to be overexpressed in several malignancies, contributing to tumor growth and metastasis. Research has focused on the therapeutic potential of targeting FGFR-2 beta (IIIb) in cancer treatment, including the development of small molecule inhibitors and monoclonal antibodies that can inhibit its activity. Moreover, understanding the structural and functional aspects of the FGFR-2 beta (IIIb) recombinant protein is crucial for drug design and the development of targeted therapies. Studies have highlighted the importance of FGFR-2 beta (IIIb) in mediating the effects of various ligands and its association with specific signaling pathways that promote oncogenic processes. In summary, the investigation of FGFR-2 beta (IIIb) recombinant protein serves as a promising avenue for uncovering new therapeutic strategies in oncology and understanding the complexities of FGFR signaling in both normal and diseased states.
