Analytical Data
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Gene name
FGFR-2 alpha (IIIc)
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简介
The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-2 alpha IIIc protein, expressed by HEK293 , with C-His, C-Avi labeled tag.
- Application
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Alternative Names
FGF R2a; FGFR2 alpha; KGFR; CD332; BBDS; BEK; BFR-1; CEK3; CFD1; ECT1; JWS; K-SAM; KGFR; TK14; TK25; FLJ98662
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Species
Human
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Source
HEK293
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Tag
C-Avi;C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P21802-1
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Expression Region
R22-E377
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Protein Length
Extracellular Domain
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Molecular Weight
70-80 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Fibroblast growth factor receptor 2 (FGFR2) is a key member of the fibroblast growth factor receptor family, which plays a critical role in various biological processes, including cell proliferation, differentiation, and angiogenesis. FGFR2 exists in several isoforms, with the IIIc isoform being particularly significant due to its implication in developmental processes and tumorigenesis. Abnormal FGFR2 signaling has been associated with several types of cancer, making it a promising target for therapeutic interventions. Research on FGFR2 α(IIIc) recombinant protein focuses on understanding its structure-function relationships and downstream signaling pathways. This knowledge aids in the development of FGFR2-targeted therapies, including monoclonal antibodies and small molecule inhibitors, which hold potential for treating FGFR2-associated malignancies. Additionally, studying FGFR2 α(IIIc) provides insights into its role in normal physiological processes, such as organogenesis and wound healing, contributing to the broader understanding of cell signaling mechanisms. The characterization of FGFR2 α(IIIc) recombinant protein is thus crucial not only for therapeutic development but also for elucidating its biological functions in health and disease.
