Analytical Data
-
Gene name
KIR3DL3/CD158z
- Application
-
Alternative Names
CD158Z; KIRC1; KIR3DL7; KIR44; CD158 antigen-like family member Z; Killer cell inhibitory receptor 1
-
Species
Human
-
Source
E. coli
-
Tag
N- His & GST
-
Purity
Greater than 90% as determined by reducing SDS-PAGE.
-
Uniprot
Q8N743
-
Expression Region
Asp147~Val410
-
Molecular Weight
65kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KIR3DL3, also known as CD158z, is a member of the killer immunoglobulin-like receptors (KIR) family, which plays a critical role in regulating the immune response, particularly in natural killer (NK) cells and T cells. Located on human chromosome 19q13.4, KIR3DL3 is characterized by its ability to recognize MHC class I molecules, contributing to the modulation of immune activation and inhibition. Research on KIR3DL3 has gained attention due to its potential implications in various diseases, including viral infections, cancer, and autoimmune disorders. Studies have demonstrated that KIR3DL3 can influence immune cell cytotoxicity and cytokine production, making it a key player in determining the outcome of immune responses. Moreover, polymorphisms in the KIR gene family are associated with different susceptibility to diseases, highlighting the importance of understanding KIR3DL3’s structure and function. Recombinant protein studies of KIR3DL3/CD158z are crucial for elucidating its molecular interactions and signaling pathways, providing insights into its role in immune regulation. By generating and characterizing recombinant KIR3DL3 proteins, researchers aim to unravel the mechanisms underlying its activity, explore its therapeutic potential, and contribute to the development of novel immunotherapies targeting KIR pathways. The ongoing research on KIR3DL3/CD158z not only enhances our understanding of immune evasion by pathogens and tumors but also opens avenues for potential interventions in immunological diseases, making it a significant focus in the fields of immunology and therapeutic development.
