Analytical Data
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基因名
IL-15R alpha & IL-15
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简介
IL-15R alpha is a high affinity receptor for IL-15 (Kd: 100 pM)[1]. IL-15R alpha binds IL-15 and thereby activating the antitumor functions of NK cells and CD8+ T cells[2]. IL-15R alpha plays an important role in memory CD8+ T cell homeostasis and lymphocyte development[3]. IL-15R alpha Protein, Human (142a.a, HEK293, Fc) is a recombinant human extracellular region of IL-15R alpha (I31-T172) with a C-Terminal Fc tag, which is produced in HEK293 cells.
- Application
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别名
Interleukin-15 receptor subunit alpha; IL-15R-alpha; IL-15RA; CD215; sIL-15R-alpha; sIL-15RA
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种属
Human
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13261-3
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表达区间
I31-T172
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蛋白长度
Partial
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分子量
60-75 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-15 (IL-15) is a crucial cytokine involved in immune responses, particularly in the development, activation, and proliferation of natural killer (NK) cells and memory CD8+ T cells. The IL-15 receptor (IL-15R) is a complex system composed of three subunits: IL-15R alpha (IL-15Rα), IL-2R beta (IL-2Rβ), and common gamma chain (γc). Among these, IL-15Rα plays a significant role in the binding and presentation of IL-15 to its receptor complex, facilitating signaling pathways that promote cell survival and proliferation. Research on recombinant forms of IL-15, particularly those fused with IL-15Rα, has garnered attention due to their potential therapeutic applications in cancer immunotherapy and the treatment of immunodeficiencies. The combination of IL-15 with its receptor alpha enhances the stability, bioavailability, and specificity of IL-15, leading to improved immune responses. Studies have shown that recombinant IL-15 and IL-15Rα fusion proteins can enhance the proliferation and function of NK cells and CD8+ T cells, making them promising candidates for clinical applications. Understanding the molecular interactions of IL-15 and IL-15Rα is essential for optimizing these recombinant proteins and developing novel immunotherapeutic strategies. This area of research is crucial for advancing our knowledge of cytokine biology and harnessing the immune system to target various malignancies and infectious diseases effectively.
