Recombinant Human Aminopeptidase N/APN Protein , His

Aminopeptidase N (APN), also known as CD13, is a zinc-dependent metallopeptidase that plays a crucial role in various physiological processes, including protein metabolism and immune response regulation. APN is widely expressed on the surface of different cell types, including immune cells, endothelial cells, and some epithelial cells. It is involved in the degradation of extracellular peptides, thus influencing signaling pathways that are vital for cell proliferation, differentiation, and migration. In addition, APN has been implicated in the pathology of several diseases, including cancer, where it can affect tumor growth and metastasis, and in various infectious diseases, as it serves as a receptor for certain pathogens. The study of recombinant APN proteins has gained significant attention for their potential applications in diagnostics and therapeutics, particularly in designing inhibitors that can selectively target APN for cancer treatment or as a means to modulate immune responses. The ability to produce APN in a recombinant form allows for detailed characterization of its structure and function, paving the way for understanding its role in disease mechanisms and developing APN-based strategies for intervention. This research is critical for exploring novel approaches to combat diseases where APN is a key player, thereby highlighting its significance in both basic biology and clinical applications.