Analytical Data
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Gene name
IL-18R alpha
- Application
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Alternative Names
CD218a; IL18Ra; IL18R1; IL1RRP; IL-1 R5; IL-1 Rrp; IL-18 R alpha; IL-18 R1; IL-18Ra
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Species
Human
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Source
HEK293
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Tag
C-Avi;C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13478
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Expression Region
A19-R329
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Molecular Weight
70-90 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-18 receptor alpha (IL-18Rα) is a critical component of the IL-18 signaling pathway, which plays a vital role in the immune response, particularly in the activation of T cells and natural killer (NK) cells. Studies have shown that IL-18, a pro-inflammatory cytokine, is involved in various autoimmune diseases, infectious diseases, and cancer progression. The receptor complex, comprising IL-18Rα and IL-18Rβ, facilitates the binding of IL-18 and initiates downstream signaling pathways that lead to the production of other cytokines, enhancing the immune response. Given its pivotal role in modulating inflammation and immune responses, IL-18Rα has emerged as a potential therapeutic target for treating various diseases. Researchers are focusing on the production of recombinant IL-18Rα protein to study its structure, function, and interaction with IL-18, as well as to explore its role in disease pathology. Additionally, the recombinant protein can serve as a valuable tool for developing inhibitors or antagonists that could block IL-18 signaling, offering new avenues for therapeutic interventions in diseases characterized by excessive inflammation or immune dysregulation. Understanding the dynamics and mechanisms of IL-18Rα will not only enhance our knowledge of immune regulation but may also lead to novel strategies for the treatment of conditions such as chronic inflammatory diseases and cancers, where modulation of the immune response is crucial. This ongoing research underscores the importance of IL-18Rα in immunology and its potential implications in clinical therapy.
