Analytical Data
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Gene name
IGF-I R
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简介
IGF-I receptor (IGF1R) mediates insulin-like growth factor effects, binding strongly to IGF1. Activation triggers PI3K-AKT/PKB and Ras-MAPK pathways, influencing cell survival, protein synthesis, and proliferation. IGF1R also signals through JAK/STAT, inhibiting JNK activation. Hybrid receptors show variable binding to IGF1 and insulin. IGF-I R Protein, Human (sf9, His-GST) is the recombinant human-derived IGF-I R protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- Application
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Alternative Names
Insulin-like growth factor 1 receptor; IGF-I receptor; CD221; IGF1R
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Species
Human
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Source
Baculovirus
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Tag
N-His;N-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P08069
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Expression Region
M954-C1367
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Insulin-like growth factor I receptor (IGF-IR) is a critical protein in cell signaling pathways that regulates growth, development, and metabolism. It is a transmembrane glycoprotein that belongs to the receptor tyrosine kinase family and is activated by its ligands, IGF-I and IGF-II. The importance of IGF-IR is underscored by its role in cellular processes such as proliferation, differentiation, and survival, making it a key player in various physiological and pathological conditions, including cancer and metabolic disorders. Research on recombinant IGF-IR proteins has gained momentum due to their potential applications in therapeutic interventions and drug development. By producing recombinant IGF-IR, scientists can study its structure, function, and interactions in detail, facilitating the identification of inhibitors that can modulate its activity in disease contexts. Furthermore, understanding the signaling pathways associated with IGF-IR can lead to novel strategies for targeting tumors that exhibit aberrant IGF signaling. Given the receptor's involvement in promoting tumorigenesis, harnessing recombinant IGF-IR for high-throughput screening of small molecules represents a promising approach in cancer therapy. Overall, the investigation of recombinant IGF-IR proteins not only enhances our understanding of fundamental biological mechanisms but also aids in the development of innovative treatments for diseases linked to dysregulated IGF signaling.
