Analytical Data
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基因名
IGF-I R
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简介
Igf1r Protein, a cell surface receptor, is involved in growth regulation and development. Dysregulation of Igf1r Protein has been linked to diseases like cancer and growth disorders. Targeting Igf1r Protein may offer potential therapeutic interventions in these conditions by modulating cell growth, inhibiting tumor progression, and managing growth-related disorders. IGF-I R Protein, Rat (HEK293, His) is the recombinant rat-derived IGF-I R protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
IGF1R; IGFR; JTK13; CD221; MGC142170; MGC142172; MGC18216
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种属
Rat
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表达系统
HEK293
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标签
C-10*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P24062
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表达区间
E31-H936
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氨基酸序列
EICGPGIDIRNDYQQLKRLENCTVIEGFLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTIDWSLILDAVSNNYIVGNKPPKECGDLCPGTLEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSVCGKRACTENNECCHPECLGSCHTPDDNTTCVACRHYYYKGVCVPACPPGTYRFEGWRCVDRDFCANIPNAESSDSDGFVIHDGECMQECPSGFIRNSTQSMYCIPCEGPCPKVCGDEEKKTKTIDSVTSAQMLQGCTILKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWNHRNLTVRSGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLRFTSTTTWKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKEGEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPTLPNGNLSYYIVRWQRQPQDGYLFRHNYCSKDKIPIRKYADGTIDVEEVTENPKTEVCGGDKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERRRRDVLQVANTTMSSRSRNTTVADTYNITDPEEFETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVPAKTTYENFMH
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蛋白长度
Partial
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分子量
45-43 kDa, 100-130 kDa&140-180 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Insulin-like growth factor I receptor (IGF-IR) is a critical protein in cell signaling pathways that regulates growth, development, and metabolism. It is a transmembrane glycoprotein that belongs to the receptor tyrosine kinase family and is activated by its ligands, IGF-I and IGF-II. The importance of IGF-IR is underscored by its role in cellular processes such as proliferation, differentiation, and survival, making it a key player in various physiological and pathological conditions, including cancer and metabolic disorders. Research on recombinant IGF-IR proteins has gained momentum due to their potential applications in therapeutic interventions and drug development. By producing recombinant IGF-IR, scientists can study its structure, function, and interactions in detail, facilitating the identification of inhibitors that can modulate its activity in disease contexts. Furthermore, understanding the signaling pathways associated with IGF-IR can lead to novel strategies for targeting tumors that exhibit aberrant IGF signaling. Given the receptor's involvement in promoting tumorigenesis, harnessing recombinant IGF-IR for high-throughput screening of small molecules represents a promising approach in cancer therapy. Overall, the investigation of recombinant IGF-IR proteins not only enhances our understanding of fundamental biological mechanisms but also aids in the development of innovative treatments for diseases linked to dysregulated IGF signaling.
